15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

White crystalline ufa;Insoluble m'madzi ndi petroleum ether, sungunuka mu ethyl acetate ndi methanol;mp ndi 115-116 ℃;Kuzungulira kwachindunji [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
Ntchito polypeptide kaphatikizidwe, monga amino acid chitetezo monomer.
O-benzyl-l-threonine adayimitsidwa mu dioxane solution ndi acylated ndi tert-butylcarbonyl azide kuti apeze zinthu zopanda pake, zomwe zidatulutsidwa ndi ethyl acetate pa pH ya 9-10 ndikusinthidwanso.
Mbali yogwira ya thymic oietin Ⅱ ya thymus secretions.Thymoietin II ndi gulu limodzi la polypeptide lopatulidwa ku thymus hormone.Imapangidwa ndi ma amino acid 49, ndipo chidutswa cha peptide chopangidwa ndi ma amino acid 5 chili ndi magwiridwe antchito ofanana ndi a thymoietin II.Chifukwa chake, chidutswa cha pentapeptide ichi chimatchedwa thymus pentapeptide.White amaundana-zouma lotayirira misa kapena ufa.
Imodzi mwamaudindo a thymus pentapeptide ndikupangitsa kusiyana kwa T cell.Imatha kusankha kusintha kwa maselo a Thy-1- prothorax kukhala ma cell a Thy-1+ T.Kusiyana kwa T cell kumalumikizidwa ndi kuchuluka kwa ma intracellular cAMP.Ntchito ina yofunika ya thymus pentapeptides ndi kumangirira ku zolandilira enieni okhwima zotumphukira magazi T maselo, kuwonjezera okhudza maselo ambiri cAMP mlingo, ndipo potero kuchititsa angapo okhudza maselo ambiri zimachitikira, amenenso ndi maziko ake immunomodulatory ntchito.Mu thupi labwinobwino, thymus pentapeptide imawonetsa chitetezo chamthupi, chomwe chitha kukulitsa kuchuluka kwa mapangidwe a E rosette ndi kutembenuka kwa splenic lymphocytes, kupititsa patsogolo magawo osiyanasiyana a chitetezo chamthupi choyambirira kapena chachiwiri, ndikuwonjezera kuchuluka kwa mtundu wa IgM ndi IgG kapena Mtundu wa IgA wopanga ma antibodies.Thymus pentapeptide kumapangitsanso phagocytosis ntchito ya macrophages, kuonjezera puloteni ndi phagocytosis ntchito ya polymorphonuclear neutrophils, kuonjezera kuzungulira oteteza okhutira, ndi kumapangitsanso chitetezo cha m`thupi ntchito ya ofiira magazi.Thymus pentapeptide imatha kuyambitsa ma CD4 ndi ma CD8 abwino, kotero kuti maselo enieni a Tc amatha kukhala ndi moyo wautali, komanso amatha kuyambitsa ma cell a Th ndikulimbikitsa kugwira ntchito kwa maselo a Ts.Ma antiinfection ndi achire a thymus pentapeptide amagwirizana ndi kupititsa patsogolo ntchito zama cell a TC.Kuchuluka koyenera kwa thymus pentapeptide kumatha kukulitsa kwambiri kupanga kwa interferon mu anti-infection chitetezo.Kulimbikitsa ndi kulimbikitsa kusiyana kwa T cell ndi kukhwima;CD4/CD8 imakonda kukhala yachibadwa poyendetsa gawo la T lymphocyte subsets;Kupititsa patsogolo ntchito ya phagocytosis ya macrophages;Kupititsa patsogolo chitetezo cha mthupi;Wonjezerani ntchito za maselo akupha zachilengedwe;Wonjezerani mlingo wa interleukin-2 kupanga ndi mawu olandirira;Kupititsa patsogolo kupanga γ interferon mu zotumphukira magazi mononuclear maselo;Limbikitsani ntchito za SOD mu seramu.
Angagwiritsidwe ntchito zilonda chotupa odwala ndi chitetezo cha m`thupi kuwonongeka pambuyo radiotherapy ndi chemotherapy.Chithandizo cha matenda a chiwindi B;Ma opaleshoni akuluakulu ndi matenda aakulu;matenda autoimmune monga nyamakazi, lupus erythematosus;Type II shuga mellitus, menopause syndrome;Munthu amene ali ndi mphamvu yofooka ya chitetezo cha mthupi.