130622-05-8 Tert-butoxycarbonyl-D-glutamic acid (methyl ester) -methyl ester

Fluoroquinolones ali ndi antibacterial spectrum yotakata, mphamvu yolimbana ndi mabakiteriya, kutsika koyipa, kupezeka kwa minofu yabwino, kupezeka kwapakamwa kwambiri, nthawi yayitali yoyang'anira ndikuwongolera bwino.Amagwiritsidwa ntchito kwambiri pochiza matenda opatsirana monga matenda a kupuma thirakiti ndi matenda a mkodzo.Kapangidwe ka fluoroquinolone antibacterial mankhwala yodziwika ndi kukhalapo kwa fluorine mu malo achisanu ndi chimodzi a quinolone kholo phata.
Komabe, m'zaka zaposachedwa 10, chifukwa cha kukakamizidwa kosankha komwe kumapangidwa ndi kugwiritsa ntchito mitundu yonse ya mankhwalawa, zovuta zosamva mankhwala zimawonjezeka, makamaka m'zaka zaposachedwa, Streptococcus pneumoniae yolimbana ndi quinolone imakhala yolimba, yomwe imalimbana ndi penicillin, maantibayotiki a macrolide ndi ma quinolone.Pa nthawi yomweyo, anapeza kuti ena fluoroquinolones angachititse QTc imeneyi kutalikitsa electrocardiogram, hepatotoxicity ndi phototoxicity, amene kuchepetsa ntchito yawo.
Pofuna kuthana ndi zofooka zomwe zili pamwambazi za fluoroquinolones, ndikofunikira kuti pakhale mankhwala atsopano okhala ndi antibacterial activation, antibacterial sipekitiramu yotakata komanso zovuta zotsutsana ndi mabakiteriya ambiri osamva mankhwala.Mndandanda wa mankhwala atsopano a fluoroquinolone-free (NFQ) omwe ali ndi 8-methoxyl ndi osiyana ndi maantibayotiki a fluoroquinolone chifukwa alibe fluorine pa malo 6 a nyukiliya ya kholo la quinolone, komabe amakhala ndi mphamvu zowononga tizilombo toyambitsa matenda.nemonoxacin ndi NFQ yatsopano yosankha bakiteriya topoisomerase inhibitor.
Poyerekeza ndi fluoroquinolones yomwe ili pamsika pano, Nenofloxacin ikuyimira kalasi yatsopano yamankhwala ampangidwe.nemonocacin (TG-873870), mankhwala atsopano a quinolone opangidwa ndi Procter & Gamble (P&G), adawonetsa ntchito yayikulu yolimbana ndi tizilombo toyambitsa matenda osiyanasiyana, kuphatikiza Staphylococcus aureus ndi Streptococcus pneumoniae yosamva mankhwala.Zotsatira za kuyesa kwa mbewa zomwe zili ndi kachilomboka zinawonetsa kuti antibacterial effect ya mankhwalawa inali yamphamvu kuposa ma quinolones ambiri omwe alipo.Kuphatikiza apo, mankhwalawa ali ndi zinthu zabwino kwambiri za pharmacokinetic ndipo amalekerera bwino.