Semaglutide

Mu Disembala 2017, US Food and Drug Administration (FDA) idavomereza mndandanda wa jakisoni wa Smeglugan peptide kuti aziwongolera zakudya komanso masewera olimbitsa thupi kuti apititse patsogolo kuwongolera shuga wamagazi kwa odwala omwe ali ndi matenda amtundu wa 2.Kuphatikiza apo, Novo ndi Nord adapanganso mtundu wapakamwa wa Rybelsus wa Smeglugin, ndipo adavomerezedwa koyamba ndi FDA mu Seputembara 2019. Awanso ndi mankhwala oyamba ovomerezeka a GLP-1 padziko lonse lapansi.matenda a shuga.M'malo mwake, Smeglugin ndi mankhwala a hypoglycemic, koma chifukwa mankhwala monga Smeglugin peptide amatha kuchedwetsa m'mimba yopanda kanthu ndikuchepetsa chilakolako, amachepetsa thupi.

Poganizira izi, mu June 2021, FDA idavomereza mwalamulo kuyang'anira kunenepa kwanthawi yayitali kapena akuluakulu onenepa.Anthu ogwira ntchito ndi: odwala osavuta omwe ali ndi BMI ≥30 kg / m2;ndi BMI> 27 kg/m2 ndikuphatikiza vuto limodzi la kunenepa kwambiri, monga kuthamanga kwa magazi, mtundu wa 2 shuga, kapena lipids yamagazi yamagazi.Chinalinso chivomerezo ichi kuti chithunzicho chinakwiriridwa kwa Smeglugin panjira ya "mankhwala amatsenga ochepetsa thupi".

Mu Epulo 2021, Smegugan adavomerezedwa ku China kuti aziwongolera shuga wamagazi kwa odwala omwe ali ndi matenda amtundu wa 2 (T2DM).Ngakhale kuwonetsa kuwonda sikuvomerezedwa ku China, kufunikira kwa kuwonda kwapakhomo sikungachitike ku China.Kuphatikiza apo, mutu waukulu wa "kuwonda ndi kuwonda", mu theka lachiwiri la 2022, Smeglugin peptide "siyinavomereze" pankhani yochepetsa thupi., Kamodzi pa nsanja zambiri zamalonda zamalonda, zakhala zikuyenda bwino pogula, ndipo kamodzi zinakhala zotsika mtengo "zotuluka m'gulu la mfumu", zomwe zinayambitsa mwachindunji mavuto a kupanga ndi kupereka kwa opanga.Nuo ndi Nord's Julayi chaka chatha adati Kuyambiranso kwa mankhwala kudzayimitsa misika yazipatala.

Kutchuka kwa peptide ya Smegugu kwatsimikiziridwanso kuchokera ku deta ya ndalama za Nuo ndi Nord.Malinga ndi zotsatira zaposachedwa za 2022 zomwe zalengezedwa ndi Nuo ndi Nord, ndalama zapachaka za bizinesi ya Nuo ndi Nord's GLP-1 inali 83.371 biliyoni Dan Ying Korona (yofanana ndi pafupifupi 81.6 biliyoni ya yuan), kuwonjezeka kwa 56% pachaka.Mwa iwo, malonda a Smeglugin anali 59.75 biliyoni Dan Ying Korona (yofanana ndi 58.5 biliyoni ya yuan), kuwonjezeka kwa 77% pachaka.Kugulitsa kwa zinthu za GLP-1 pamtundu wa matenda a shuga a 2 ku China kwakwera ndi 102% ku Dan Ying Krone.

Zachidziwikire, kuphulika kwa Smeglugin m'malo ochepetsa thupi kumagwirizana kwambiri ndi zotsatira zake."Yakwana nthawi yoti mudye, kumwa ndi kumwa, kutenga mapaundi 5, kutaya mapaundi 30 mu Januwale" ndi zina zotero.Kuonjezera apo, "kugona pansi" kungakhale kochepa kwambiri, komwe kwakopa maso osawerengeka ku Smegtu peptides, yomwe poyamba imadziwika kuti "mankhwala amatsenga a kuwonda".Komabe, asing'anga ena anena kuti Simei Gulu peptide ili ndi zoposa 2/3 zomwe zimagulitsidwa ku China kuti zichepetse thupi, osati matenda a shuga.Kumbali imodzi Pankhani ya Smeglugan peptide ngati mankhwala osokoneza bongo, pali zoopsa zobisika pachitetezo chamankhwala apamwamba.

Dziwani kuti zoweta kafukufuku mfundo za mankhwala zimachokera lalikulu -kulukulu odwala kunenepa kwambiri.Kwa anthu omwe ali ndi mafuta ochepa kapena olemera kwambiri (BM <27kg/m2), ubwino ndi zoopsa zomwe zingatheke sizikudziwikabe.Kuphatikiza apo, kuwonjezera pa machitidwe a hypoglycemia omwe ndi mankhwala a hypogenal omwe amapezeka mumankhwala a hypoglycemic, zomwe zimachitika m'mimba zimawonekera, komanso kuchuluka kwa nseru, kudzimbidwa, kusanza ndi kutsekula m'mimba kumafika 82.8%.7%.Chofunikira kwambiri ndichakuti Smeglugin sanavomerezedwe kuti aziwonetsa kuwonda ku China.Vuto la njira za mankhwala ndi kugwiritsa ntchito mankhwala osokoneza bongo kwa anthu otere ndiloyenera kusamala.