53267-93-9 Tert-butoxycarbonyl-L-Tyrosine(methyl)-OH

Khadi bei oxytocin (Carbetocin) ndi mtundu wa kaphatikizidwe kwa nthawi yaitali ndi makhalidwe a agonist oxytocin 8 peptide zili, matenda ndi pharmacological katundu ofanana ndi chilengedwe kupanga oxytocin.Mofanana ndi oxytocin, cabetin imamangiriza ku oxytocin zolandilira mu minofu yosalala ya chiberekero, zomwe zimapangitsa kuti chiberekero chipitirire, kuchulukitsa maulendo ake ndikuwonjezera kugwedezeka kwa chiberekero pamwamba pa kutsekemera koyambirira.Miyezo ya oxytocin zolandilira m'chiberekero ndi yotsika panthawi yomwe sali oyembekezera ndipo imawonjezeka panthawi yomwe ali ndi pakati, pofika pachimake pakubadwa.Choncho, cabetin alibe mphamvu pa chiberekero sanali pakati, koma ogwira uterine contractions pa chiberekero pakati ndi chiberekero pambuyo kubadwa.Kaya kudzera m'mitsempha kapena mkati, chiberekero chimagunda mofulumira, kufika mphamvu yotsimikizika mkati mwa mphindi ziwiri.Mlingo umodzi wa capetin wolowetsedwa m'mitsempha umagwira ntchito m'chiberekero kwa pafupifupi ola limodzi, zomwe zimalepheretsa kutuluka kwa magazi pambuyo pobereka.Mafupipafupi ndi matalikidwe a contractions pambuyo pobereka makonzedwe a carpeine anali atali kuposa a oxytocin.Kafukufuku wasonyeza kuti atapatsidwa mlingo umodzi wa 100μg m'mitsempha mwamsanga pambuyo pa opaleshoni pansi pa epidural kapena lumbar anesthesia, carbetin imakhala yopambana kwambiri kuposa placebo poletsa uterine hypotonia ndi kuchepetsa kutuluka kwa magazi pambuyo pobereka.Carpeine yoperekedwa kumayambiriro kwa nthawi yobereka ingathandizenso kuti chiberekero chichiritsidwe.
Kabetin amamangirira ku oxytocin zolandilira mu minofu yosalala ya chiberekero kuti chiberekero chigwire mwamphamvu, kuonjezera kufupikitsa kwake ndikuwonjezera kulimba kwa chiberekero.Mlingo umodzi wa carbetin ukhoza kuperekedwa nthawi yomweyo mwana wosabadwayo atangobereka kuti asatulutse magazi.Zapezeka kuti pambuyo pobereka mtsempha jekeseni wa oxytocin pamodzi ndi makonzedwe a cabetin angathandize kupewa kutaya magazi pambuyo pobereka.Pambuyo cesarean gawo, ntchito cabetin pamodzi oxytocin akhoza kulimbikitsa uterine chidule, kuchepetsa kuchuluka kwa magazi pambuyo cesarean gawo, zotsatira zake ndi bwino kuposa hemabate.Kwa amayi omwe ali ndi chiberekero cha cicatritic, placenta previa ndi zina zomwe zimakhala ndi chiopsezo chachikulu cha kutaya magazi pambuyo pobereka, carbetin imatha kulepheretsa kutulutsa magazi pambuyo pobereka.Amagwiritsidwa ntchito popanga opaleshoni ya epidural kapena lumbar pambuyo pa opaleshoni kuti ateteze kufooka kwa chiberekero ndi kutaya magazi pambuyo pobereka.