22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide imadziwikanso kuti Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, ndi ipratropium bromide.Ndi woyera crystalline ufa ndi kukoma kowawa.Malo osungunuka 232 ℃-233 ℃.Kusungunuka m'madzi, kusungunuka pang'ono mu Mowa, kusungunuka muzitsulo zina za organic.Dzina la mankhwala: Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Ndi anticholinergic mankhwala, amene ali ndi mphamvu yosangalala kwambiri bronchial yosalala minofu ndi antiasthmatic zotsatira aakulu obstructive m`mapapo mwanga matenda.Zotsatira zake ndizodziwikiratu, zofulumira komanso nthawi yayitali.Ipratropium bromide imayang'aniranso katulutsidwe ka tiziwalo timene timatulutsa ntchofu komanso imathandizira kusuntha kwa ciliary, motero kumachepetsa kutsekeka kwa sputum kuti mpweya wabwino ukhale wabwino.Pakadali pano, kuchepa kwa sputum kumachepetsanso bronchospasm yomwe imayambitsidwa ndi kuyabwa kwa bronchial.Pofuna kupewa komanso kuchiza matenda a mphumu ya bronchial ndi chifuwa chachikulu cha mphumu, makamaka kwa odwala omwe sangathe kulekerera kugwedezeka kwa β-agonist, tachycardia.Izi zitha kugwiritsidwa ntchito limodzi ndi beta-agonists kuti apititse patsogolo mphamvu za wina ndi mzake, monga kuphatikiza ndi finoterol kupanga aerosol (BERODU - AL) ya mphumu, bronchitis ndi emphysema.Poyerekeza ndi β-adrenergic receptor stimulants (mwachitsanzo, isopropyl epinephrine), mankhwalawa amakhala ndi zotsatira zochepa zamtima, komanso poyerekeza ndi zolimbikitsa za β2-receptor (mwachitsanzo, Suquanling), mankhwalawa ali ndi mphamvu zowongolera kuchuluka kwa phlegm.
Utsi inhalation.40 ~ 80μg kamodzi, 2 ~ 4 pa tsiku.Mukamagwiritsa ntchito, chotsani choyamba chipolopolo cha chipolopolo, ikani chipolopolo cha chivundikirocho pamphuno, tembenuzirani botolo mozondoka, khalani ndi chipolopolo pakamwa, yesetsani kukhosi, kuyamwa mpweya nthawi yomweyo, kukanikiza mphuno. pa valve, lowetsani madziwo, gwirani mpweya wanu kwa kamphindi.Bwerezani chithunzithunzi pamwambapa kamodzi ngati kuli kofunikira.Aerosol: 0.025% yankho.Piritsi: 10mg/piritsi.
Poyizoni woopsa wa anticholinergic amatha kuthandizidwa ndi cholinesterase inhibitors.
The chokhwima zochita za ipratropium bromide ndi ofanana ndi atropine, amene angayambitse palpitations, mutu, chizungulire, mantha, nseru, kusanza, kupweteka kwa m'mimba, kunjenjemera, kusaona bwino, pakamwa youma, chifuwa, dysuria, aggravation wa zizindikiro kupuma ndi zidzolo.
Ipratropium bromide ndi muscarinic antagonist, bronchodilator, ndi isopropyl mchere wa AtropineN.
Ipratropiumbromide ndi Formoterol zimaphatikizidwa pang'onopang'ono kuteteza mapapu ku kutupa kosatha ndi kukulitsa mapapu, kuchepetsa ma neutrophils mwa kuletsa ntchito kudzera pa MMP-9.Ipratropiumbromide(1nM) idachulukitsa kwambiri calcium bromide, kuchepetsa kubalalitsidwa patsogolo ndikumangirira annexin-V.Pambuyo pa chithandizo cha Ipratropiumbromide, hemolysis idakula pang'ono koma kwambiri.Ipratropiumbromide imayambitsa kufa kwa maselo ofiira a magazi kapena eryptosis, makamaka chifukwa cha kukondoweza kwa calcium.
Ipratropium dry powder inhalation (DPI) inali bronchodilator yogwira mtima pa akavalo opumula pa mlingo wa 2400 mg / kavalo, osakhudzidwa pang'ono pamtunda wapamwamba wa airway panthawi yochira.Mu makoswe othandizidwa ndi cadmium, Ipratropium idachepetsa kwambiri kulowa kwa cell yotupa ya parenchymal ndikuwona zilonda zam'mapapo zomwe zimakhudzidwa.Ipratropium imateteza pang'ono mapapu ku kutupa mwa kuchepetsa kulowetsedwa kwa neutrophil.Mu Guinea nkhumba tracheal yosalala minofu, Ipratropium ndi mdani amene amaletsa prebound muscarinic inhibitory receptor wa mapapu parasympathetic mitsempha.Ipratropium yasonyezedwanso kuti ndi mdani wamphamvu pambuyo pomanga muscarinic inhibitory receptors.Ipratropium imachepetsa kusintha kwakukulu kwa kupanikizika pachifuwa ndikuwonjezera kutsata kwamphamvu (Cdyn) mu kupuma kwamadzi (kuwonjezera Pplmax) ndi kukana kwa pulmonary (RL) mu akavalo.