166108-71-0 Fmoc-AEEA-OH

166108-71-0 Fmoc-AEEA-OH ndi cholumikizira cha ADC chomwe chimagwiritsidwa ntchito popanga ma antibody-drug conjugates (ADCs).Fmoc-8-amino-3,6-dioxaoctanoic acid ndi PEG-based PROTAC linker yomwe ingagwiritsidwe ntchito popanga PROTACs.

166108-71-0 Fmoc-AEEA-OH ingakhalenso imodzi mwa Semaglutide Intermediates.

Chotsatira chachikulu cha semaglutide ndikuchiza matenda amtundu wa 2 pochepetsa kuchuluka kwa shuga m'magazi.Imatsanzira timadzi ta insulini ngati peptide-1, yomwe imathandizira katulutsidwe ka insulini ndikuletsa kutulutsidwa kwa glucagon, potero kumachepetsa kuchuluka kwa shuga m'magazi.Semaglutide sichithandizira kuti pakhale chiopsezo cha hypoglycemia poyerekeza ndi mankhwala ochiritsira a insulin chifukwa njira yake yochitira zinthu imakhala yovuta komanso yolondola.Posintha kuchuluka kwa insulin ndi glucagon, somalitide imatha kuthandiza anthu omwe ali ndi matenda amtundu wa 2 kuti azitha kuyang'anira shuga wawo wamagazi.

Kuphatikiza pakuchepetsa shuga wamagazi, semaglutide imathanso kuchepetsa thupi.Ichi ndi chifukwa chilakolako suppressant kwenikweni.semaglutide imayambitsa ntchito ya satiety center mu hypothalamus, yomwe imachepetsa chilakolako.Phindu lalikulu la semaglutide pamankhwala ena ochepetsa thupi ndikuti limataya thupi ndikuwongolera insulin kukana komanso kuwongolera shuga wamagazi.Izi zimapangitsa kukhala njira yabwino kwambiri yothandizira odwala omwe ali ndi matenda a shuga omwe ali ndi kunenepa kwambiri.

Kuphatikiza apo, semaglutide imathandizira pancreatic ntchito ndikuchepetsa mayankho otupa m'maselo a pancreatic islet.Amateteza ma islet cell kuti asawonongeke chifukwa cha shuga komanso amathandizira kusinthika kwa ma islet cell.Izi ndizofunikira makamaka kwa anthu omwe ali ndi matenda a shuga amtundu wa 2, chifukwa kuwonongeka kwa ma islet cell kungayambitse kulephera kwa islet.

Ponseponse, semaglutide ndi mankhwala othandiza kwambiri komanso otetezeka pochiza matenda amtundu wa 2.Zimathandizira odwala kuwongolera bwino matenda a shuga komanso kuchepetsa zovuta pochepetsa kuchuluka kwa shuga m'magazi, kuchepetsa kulemera kwa thupi, kukonza magwiridwe antchito a islet, ndikuteteza ma islet cell.Maphunziro amtsogolo adzafufuzanso kuthekera kwa somatostatin pochiza matenda ena, monga NAFLD ndi kunenepa kwambiri.