13590-42-6 H-Asp(OBzl)-NCA

Kafukufuku wa Biochemical:
Mu kaphatikizidwe ka peptide, H-Asp(OBzl)-NCA imakhala ngati chomangira chofunikira pakuphatikizika kwa unyolo wa peptide wokhala ndi ma aspartic acid.
Gulu lake la benzyl ester limakhala ngati gulu loteteza, lolola kuti pakhale zosintha zinazake za mankhwala panthawi ya peptide chain synthesis, yomwe imatha kuchotsedwa pansi pamikhalidwe yoyenera kuti ipeze mndandanda wa aspartic acid.
M'maphunziro osintha mapuloteni kapena ma peptide, H-Asp(OBzl) -NCA itha kugwiritsidwa ntchito kuyambitsa zosintha zinazake zamankhwala kuti zifufuze momwe zosinthazi zimakhudzira zochitika zachilengedwe kapena kuyanjana ndi mamolekyu ena a protein kapena peptide.
Kupeza Mankhwala:
H-Asp(OBzl) -NCA imatha kukhala ngati choyambira chopangira kapena chapakati cha mamolekyu amankhwala, kulola kukhazikitsidwa kwazinthu zinazake zamakemikolo panthawi yopanga mankhwala kuti apeze omwe akufuna kugwiritsa ntchito mankhwala achilengedwe.
Kudzera mu zochita ndi zidutswa za mankhwala kapena biologically yogwira mamolekyu, atsogolere kaphatikizidwe mankhwala peptide ofotokoza kapena heterocyclic mankhwala ndi enieni achire zotsatira.
M'njira zopezera mankhwala, H-Asp(OBzl)-NCA itha kugwiritsidwanso ntchito pakuwunika kwapamwamba komanso kuyesa kwachilengedwe kuti awunike zochita za ma peptide osiyanasiyana kapena ofuna mankhwala.
Makampani Azamankhwala:
M'makampani opanga mankhwala, H-Asp(OBzl)-NCA imagwira ntchito ngati zopangira kapena zapakatikati popanga mankhwala ochiritsira a peptide.
Kudzera mu condensation zimachitikira ndi ena amino zidulo kapena zidutswa za mankhwala, akhoza atsogolere kaphatikizidwe mankhwala peptide ndi yeniyeni zochita zamoyo, monga mankhwala, mahomoni, enzyme inhibitors, ndi zina.
Gulu la benzyl ester lomwe likupezeka m'mapangidwe ake limateteza carboxylic acid ya aspartic acid, zomwe zimathandizira kukhazikika komanso kusinthika kwa unyolo wa peptide panthawi ya kaphatikizidwe.